IMG-EN-AS-65111-01.jpg
Peptides

PKCd (8-17), PKCd Inhibitor - 1 mg

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  • Cat.Number : AS-65111
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This peptide is derived from the V1 domain of protein kinase C (PKC)d. It inhibits phorbol 12-myristate 13-acetate (PMA)-induced PKCd translocation and activation. Inhibition of PKCd reduces ischemia damage in cardiac and cerebral cells, induces proliferation of fibroblasts, and inhibits graft coronary artery disease in mice.

Specifications

Chemistry
Sequence one letter code
  • SFNSYELGSL
Sequence three letter code
  • H-Ser-Phe-Asn-Ser-Tyr-Glu-Leu-Gly-Ser-Leu-OH
Molecular Formula
  • C50H73N11O18
Molecular Mass/ Weight
  • 1116.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse, rat

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References

Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC

PNAS . 2001 Sep 25 ; 98(20) 11114 | DOI : https://doi.org/10.1073/pnas.191369098

  • L. Chen
  • et al

Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors

J Mol Cell Cardiol . 2003 Aug 01 ; 35(8) 895 | DOI : https://doi.org/10.1016/S0022-2828(03)00142-1

  • M. Braun
  • D. Mochly-Rosen

Opposing cardioprotective actions and parallel hypertrophic effects of δPKC and ɛPKC

PNAS USA . 2001 Sep 25 ; 98(20) 11114 | DOI : https://doi.org/10.1073/pnas.191369098

  • L. Chen
  • et al

Opposing effects of δ- and ζ-protein kinase C isozymes on cardiac fibroblast proliferation: use of isozyme-selective inhibitors

J Mol Cell Cardiol . 2003 Aug 01 ; 35(8) 895 | DOI : https://doi.org/10.1016/S0022-2828(03)00142-1

  • M. Braun
  • D. Mochly-Rosen

Suppression of Graft Coronary Artery Disease by a Brief Treatment With a Selective εPKC Activator and a δPKC Inhibitor in Murine Cardiac Allografts

Circulation . 2004 Sep 14 ; 110(11-1) 194 | DOI : https://doi.org/10.1161/01.CIR.0000138389.22905.62

  • M. Tanaka
  • et al

Protein Kinase C δ Mediates Cerebral Reperfusion Injury In Vivo

J Neurosci . 2004 Aug 04 ; 24(31) 6880 | DOI : https://doi.org/10.1523/JNEUROSCI.4474-03.2004

  • R. Bright
  • et al