PKCe Peptide Substrate - 1 mg
- Cat.Number : AS-27183
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The peptide sequence ERMRPRKRQGSVRRRV corresponds to pseudosubstrate region of the e-isotype of protein kinase C (PKCe) with an alanine to serine substitution. PKCe exhibits an apparent specificity for the native peptide (Km = 68 mM).
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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Citations
Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii
J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200
- AJ. O'Donoghue
A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors
J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531
- X. Zhao
References
Expression, purification, and characterization of protein kinase C-epsilon
JBC . 1990 May 05 ; 265(13) 7301 | DOI : https://doi.org/10.1016/S0021-9258(19)39114-8
- D. Schaap
- PJ. Parker
Unique substrate specificity and regulatory properties of PKC-ε: a rationale for diversity
FEBS Lett . 1989 Jan 30 ; 243(2) 351 | DOI : https://doi.org/10.1016/0014-5793(89)80160-7
- D. Schaap
- et al