Peptides

Plasmepsin II FRET Substrate, Hemoglobin Fragment, 2837b - 1 mg

$261.00
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  • Cat.Number : AS-62050
  • Availability :
    In stock

Quantity

The sequence of this synthetic peptide is based on the primary site of cleavage by plasmepsin II (PM II) within hemoglobin (Hb), and numbering of the peptide corresponds to the residue within the α-chain of Hb. Plasmepsins are involved in the early steps of hemoglobin degradation. They are able to recognize intact hemoglobin and make an initial cleavage in the B helix of the hemoglobin α-chain between Phe-33 and Leu-34.

Specifications

Chemistry
Sequence one letter code
  • EDANS-CO-CH2-CH2-CO-ALERMFLSFP-Dap(DABCYL)OH
Sequence three letter code
  • EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap(DABCYL)-OH
Molecular Mass/ Weight
  • 1896.2
Properties
Absorbance (nm)
  • 340
Emission (nm)
  • 490
Modification
Conjugation type
  • Double dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Plasmodium

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References

Distal Substrate Interactions Enhance Plasmepsin Activity

J Biol Chem . 2005 Feb 01 ; 280(8) 6890 | DOI : https://doi.org/10.1074/jbc.M412086200

  • E. Istvan
  • D. Goldberg

Hemoglobin-degrading Plasmepsin II Is Active as a Monomer

J Biol Chem . 2006 Dec 01 ; 281(50) 38682 | DOI : https://doi.org/10.1074/jbc.M608535200

  • J. Liu
  • et al