IMG-EN-AS-60248-1-01.jpg
Peptides

Prosaptide TX14(A)

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  • Cat.Number : AS-60248-1
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This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.

Specifications

Chemistry
Sequence one letter code
  • TaLIDNNATEEILY
Sequence three letter code
  • H-Thr-D-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr-OH
CAS registry number
  • 196391-82-9
Molecular Formula
  • C69H110N16O26
Molecular Mass/ Weight
  • 1579.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use

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Citations

Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats

Anesthesiology. . 2000 Nov 01 ; 93(5) 1271 | DOI : 10.1097/00000542-200011000-00021

  • NA. Calcutt

Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide™ TX14(A)

Neurosci Lett . 1999 Jul 23 ; 270(1) 29 | DOI : https://doi.org/10.1016/S0304-3940(99)00461-9

  • D. Otero

Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells

FASEB J . 1998 Mar 01 ; 12(3) 307 | DOI : 10.1096/fasebj.12.3.307

  • WM. Campana

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

Proc Natl Acad Sci U S A . 1997 Apr 29 ; 94(9) 4778 | DOI : 10.1073/pnas.94.9.4778

  • M. Hiraiwa

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Proc Natl Acad Sci U S A. . 2013 May 20 ; 110(23) 9529 | DOI : 10.1073/pnas.1219004110

  • RC. Meyer

References

Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides

PNAS USA . 1997 Apr 29 ; 94(9) 4778 | DOI : https://doi.org/10.1073/pnas.94.9.4778

  • M. Hiraiwa
  • et al

Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells

FASEB J . 1998 Mar 01 ; 12(3) 307 | DOI : https://doi.org/10.1096/fasebj.12.03.307

  • M. Campana
  • et al

Protection of Sensory Function and Antihyperalgesic Properties of a Prosaposin-derived Peptide in Diabetic Rats

Anesthesiol . 2000 Nov 01 ; 93(5) 1271 | DOI : https://doi.org/10.1097/00000542-200011000-00021

  • NA. Calcutt
  • et al

Retro-Inverso Prosaptide Peptides Retain Bioactivity, Are Stable In Vivo, and Are Blood-Brain Barrier Permeable

Pharmacol. . 2000 Oct 01 ; 295(1) 190

  • E. Taylor
  • et al