Peptides

PrP (106-126), prion protein - 1 mg

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  • Cat.Number : AS-61160
  • Availability :
    In stock

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Prion protein (PrP), also known as CD230, is mainly produced in the nervous sytem. PrP exists as different isoforms, among which the normal PrPc, and the 'scrapie' isoform PrPSc. PrPSc is misfolded and associated to multiple disorders including bovine spongiform encephalopathy, Gerstmann-Straüssler-Scheindker disease (GSS) and the Creutzfeldt-Jakob disease. It contains a much higher beta-sheet content than PrPc, and tends to form protease-resistant aggregates. A hypothesis to support the propoagation of these aggregates and their role in neurodegeneration is the change from normal PrPc to PrPSc triggered by its interaction with PrPSc (conformation conversion hypothesis).
PrP 127-147 forms filamentous structures ressembling scrapie-associated fibrils, but possesses a lower amyloidogenic potential than PrP 106-126.
This peptide increases membrane microviscosity, intracellular Ca2+ concentration and cell migration in circulating leucocytes, and oxygen production in monocytes and neutrophils. It also induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell lines. PrP (106–126) stimulates leucocyte migration in a dose-dependent manner.

Specifications

Chemistry
Sequence one letter code
  • KTNMKHMAGAAAAGAVVGGLG
Sequence three letter code
  • H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH
CAS registry number
  • 148439-49-0
Molecular Formula
  • C80H138N26O24S2
Molecular Mass/ Weight
  • 1912.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Activation effects of a prion protein fragment [PrP-(106-126)] on human leucocytes

Biochem J . 1996 Dec 01 ; 320(2) 563 | DOI : https://doi.org/10.1042/bj3200563

  • L. Diomede
  • et al

Prion protein fragment 106–126 induces apoptotic cell death and impairment of L-type voltage-sensitive calcium channel activity in the GH3 cell line

J Neurosci Res . 1998 Nov 01 ; 54(3) 341 | DOI : https://doi.org/10.1002/(SICI)1097-4547(19981101)54:3<341::AID-JNR5>3.0.CO;2-G

  • T. Florio
  • et al