IMG-EN-AS-62404-01.jpg
Peptides

PUMA BH3 - 1 mg

$254.00
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  • Cat.Number : AS-62404
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    In stock

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This is a PUMA (p53 upregulated modulator of apoptosis) BH3 domain peptide. PUMA together with Bcl-xL, and cytoplasmic p53 coordinates p53 functions. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EEQWAREIGAQLRRMADDLNAQYER
Sequence three letter code
  • H-Glu-Glu-Gln-Trp-Ala-Arg-Glu-Ile-Gly-Ala-Gln-Leu-Arg-Arg-Met-Ala-Asp-Asp-Leu-Asn-Ala-Gln-Tyr-Glu-Arg-OH
Molecular Formula
  • C128H202N42O43S1
Molecular Mass/ Weight
  • 3049.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

PNAS . 2008 Dec 23 ; 105(51) 20327 | DOI : 10.1073/pnas.0808036105

  • J. Chipuk

References

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

PNAS USA . 2001 Sep 25 ; 98(20) 11318 | DOI : https://doi.org/10.1073/pnas.201208798

  • J. Han
  • et al

PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53

Science . 2005 Sep 09 ; 309(5741) 1732 | DOI : 10.1126/science.1114297

  • J. Chipuk
  • et al

PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells

Mol Cell . 2001 Mar 01 ; 7(3) 673 | DOI : https://doi.org/10.1016/S1097-2765(01)00213-1

  • J. Yu
  • et al

PUMA, a Novel Proapoptotic Gene, Is Induced by p53

Mol Cell . 2001 Mar 01 ; 7(3) 683 | DOI : https://doi.org/10.1016/S1097-2765(01)00214-3

  • K. Nakano
  • K. Vousden