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Peptides

Secretoneurin - 1 mg

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  • Cat.Number : AS-62673
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This peptide is amino acids 154 to 186 fragment of secretogranin II, designated secretoneurin. Secretoneurin is a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II. Secretoneurin acts as direct angiogenic cytokine, inhibits endothelial cell (EC) apoptosis, stimulates EC proliferation, and activates the mitogen-activated protein kinase (MAPK) system and the Akt pathway.

Specifications

Chemistry
Sequence one letter code
  • TNEIVEEQYTPQSLATLESVFQELGKLTGPSNQ
Sequence three letter code
  • H-Thr-Asn-Glu-Ile-Val-Glu-Glu-Gln-Tyr-Thr-Pro-Gln-Ser-Leu-Ala-Thr-Leu-Glu-Ser-Val-Phe-Gln-Glu-Leu-Gly-Lys-Leu-Thr-Gly-Pro-Ser-Asn-Gln-OH
CAS registry number
  • 149146-12-3
Molecular Formula
  • C159H252N40O58
Molecular Mass/ Weight
  • 3652.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • mouse, rat

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Citations

GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin

Proc Natl Acad Sci U S A. . 2013 May 20 ; 110(23) 9529 | DOI : 10.1073/pnas.1219004110

  • RC. Meyer

References

SwePep, a Database Designed for Endogenous Peptides and Mass Spectrometry

Mol. Cell. Proteom . 2006 Jun 01 ; 5(6) 998 | DOI : https://doi.org/10.1074/mcp.M500401-MCP200

  • M. Fälth
  • et al

Secretoneurin—a neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C)

Neurosci. . 1993 Mar 01 ; 53(2) 359 | DOI : https://doi.org/10.1016/0306-4522(93)90200-Y

  • R. Kirchmair
  • et al

Secretoneurin, an Angiogenic Neuropeptide, Induces Postnatal Vasculogenesis

Circulation . 2004 Aug 23 ; 110 1121 | DOI : https://doi.org/10.1161/01.CIR.0000139884.81390.56

  • R. Kirchmair
  • et al