IMG-EN-AS-61235-01.jpg
Peptides

T20, Enfuvirtide - 1 mg

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  • Cat.Number : AS-61235
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This 36-residue synthetic peptide strongly inhibits HIV-1 viral fusion with CD4 cells with an EC50 of 1 ng/ml.
It is a peptide mimetic of an essential region within the viral envelope glycoprotein gp41 that functions by blocking gp41 structural rearrangements at a transitional pre-fusion conformation.

Specifications

Chemistry
Sequence one letter code
  • Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2
Sequence three letter code
  • Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
CAS registry number
  • 74038-65-6
Molecular Formula
  • C204H301N51O64
Molecular Mass/ Weight
  • 4492.2
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • HIV

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Citations

Phosphorylation of HIV Nef by cAMP-dependent protein kinase

Virology. . 2005 Jan 20 ; 331(2) 367 | DOI : 10.1016/j.virol.2004.11.004

  • PL. Lia

References

T20/DP178, an Ectodomain Peptide of Human Immunodeficiency Virus Type 1 gp41, Is an Activator of Human Phagocyte N-Formyl Peptide Receptor

Blood . 1990 Jan 22 ; 93(11) 3885 | DOI : https://doi.org/10.1182/blood.V93.11.3885

  • SB. Su
  • et al

HIV-1 Membrane Fusion Mechanism:  Structural Studies of the Interactions between Biologically-Active Peptides from gp41

Biochem . 1996 Oct 22 ; 35(42) 13697 | DOI : https://doi.org/10.1021/bi9606962

  • MK. Lawless
  • et al