Tyrosinase (368-376) [Asp370] - 1 mg
- Cat.Number : AS-61456
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This tumor antigenic peptide presented by HLA-A2 antigen to CTLs, is a tyrosinase fragment. Tyrosinase is a membrane-bound protein involved in the melanin synthesis pathway that is expressed by virtually all primary melanoma lesions and by most of metastatic lesions.
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References
Destructive Cleavage of Antigenic Peptides Either by the Immunoproteasome or by the Standard Proteasome Results in Differential Antigen Presentation
J Immunol . 2006 Jan 15 ; 176(2) 1053 | DOI : https://doi.org/10.4049/jimmunol.176.2.1053
- J. Chapiro
- et al
Effects of interleukin-12 on the immune response to a multipeptide vaccine for resected metastatic melanoma
J Clin Oncol . 2001 Sep 15 ; 19(18) 3836 | DOI : 10.1200/JCO.2001.19.18.3836
- P. Lee
- et al
Expansion of Melanoma-specific Cytolytic CD8+ T Cell Precursors in Patients with Metastatic Melanoma Vaccinated with CD34+ Progenitor-derived Dendritic Cells
JEM . 2004 Jun 01 ; 199(11) 1503 | DOI : https://doi.org/10.1084/jem.20032118
- S. Paczesny
- et al