IMG-EN-AS-23614-01.jpg
Peptides

VIP, human, porcine, rat, FAM-labeled - 0.5 mg

$550.00
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  • Cat.Number : AS-23614
  • Availability :
    In stock

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This is a fluorescent (FAM)-labeled VIP, Abs/Em=492/518 nm. The 28-amino acid neuropeptide VIP (Vasoactive Intestinal Peptide) is a neurotransmitter and a neuromodulator. VIP is broadly distributed in the peripheral and central nervous systems. It has an amino acid sequence identity of 68% with pituitary adenylate cyclase-activating polypeptide (PACAP). VIP and PACAP inhibit TNF-a, IL-1ß, IL-6, and NO production by lipopolysaccharide (LPS)-activated microglia. Both regulate the production of proinflammatory factors at a transcriptional level by inhibiting p65 nuclear translocation and nuclear factor-kB-DNA binding. As well, VIP relaxes the smooth muscle of the respiratory, gastrointestinal and reproductive tracts, stimulates exocrine and endocrine secretion, increases the survival time of neurons, and promotes the proliferation of untransformed and cancer cells.

Specifications

Chemistry
Sequence one letter code
  • FAM-HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2
Sequence three letter code
  • FAM-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Molecular Formula
  • C168H244N44O48S1
Molecular Mass/ Weight
  • 3684.3
Properties
Absorbance (nm)
  • 492
Emission (nm)
  • 518
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, Porcine

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References

Cleavage of vasoactive intestinal peptide at multiple sites by autoantibodies

JBC . 1991 Aug 25 ; 266(24) 16128 | DOI : https://doi.org/10.1016/S0021-9258(18)98525-X

  • S. Paul
  • et al

Differential Involvement of the Ras and Rap1 Small GTPases in Vasoactive Intestinal and Pituitary Adenylyl Cyclase Activating Polypeptides Control of the Prolactin Gene

JBC . 2003 Dec 01 ; 278(51) 51386 | DOI : https://doi.org/10.1074/jbc.M308372200

  • D. Romano
  • et al

Overexpression of PACAP in Transgenic Mouse Pancreatic β-Cells Enhances Insulin Secretion and Ameliorates Streptozotocin-induced Diabetes

Diabetes . 2003 May 01 ; 52(5) 1155 | DOI : https://doi.org/10.2337/diabetes.52.5.1155

  • K. Yamamoto
  • et al

Phosphonate Ester Probes for Proteolytic Antibodies

JBC . 2001 Jul 01 ; 276(30) 28314 | DOI : https://doi.org/10.1074/jbc.M102530200

  • S. Paul

The many faces of VIP in neuroimmunology: a cytokine rather a neuropeptide?

FASEB . 2004 Sep 01 ; 18(12) 1325 | DOI : https://doi.org/10.1096/fj.03-1440hyp

  • D. Poso
  • M. Delgado

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia

JLB . 2003 Jan 01 ; 73(1) 155 | DOI : https://doi.org/10.1189/jlb.0702372

  • M. Delgado
  • et al

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide: players in innate and adaptive immunity.

Cell Mol Biol . 2003 Mar 01 ; 49(2) 127 | DOI : PMID: 12887096

  • D. Ganea
  • et al