Natriuretic Peptides

Natriuretic peptides play a major role
in the RAAS system

Natriuretic peptides are a family of naturally occurring peptides that play a major role in down-regulating the activity of the renin-angiotensin-aldosterone system: they regulate circulatory homeostasis, induce natriuresis and vasodilatation.

Three major natriuretic peptides have been discovered:

  • atrial natriuretic peptide (ANP)- secreted largely by the atria
  • brain natriuretic peptide (BNP) - produced by the ventricles
  • C-type natriuretic peptide (CNP)- located in peripheral blood vessels.


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  • Maeda, K. et al. Heart J. 135, 825 (1998)
  • Cardarelli, R. et al. J. Am. Board Fam. Prac. 16, 327 (2003)
  • Struthers, A. BMJ 308, 1615 (1994)
  • Levin, E. et al. N. Engl. J. Med. 339, 321 (1998)
  • Cheung, B. et al. JAMA 280, 1983 (1998)
  • Kalra, P. et al. Eur. Heart J. 22, 997 (2001)
  • Ee Lemos, JA. et al. Lancet 362, 316 (2005)
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