IMG-EN-AS-20752-01.jpg
Peptides

Gastrin-1, rat - 1 mg

$164.00
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  • Cat.Number : AS-20752
  • Availability :
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Like human Gastrin-1 “Little Gastrin,” rat Gastrin-1 “Little Gastrin” contains 17 amino acids, but differs from human Gastrin by 3 amino acids at the C-terminus. Secretion of Gastrin is induced by food intake and causes the release of gastric acid. Synthesized by the G cells in the gastric mucosa, it is one of the major bioactive forms of Gastrin (the other bioactive form is Gastrin-34). Both Gastrin-17 and Gastrin-34 are carboxy-amidated and partially tyrosine sulfated. Binding of Gastrin to the CCK2/gastrin receptor requires carboxy-amidation, however sulfation is not necessary for binding to the receptor.

Specifications

Chemistry
Sequence one letter code
  • Pyr-RPPMEEEEEAYGWMDF-NH2
Sequence three letter code
  • Pyr-Arg-Pro-Pro-Met-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2
CAS registry number
  • 81123-06-0
Molecular Formula
  • C94H128N22O31S2
Molecular Mass/ Weight
  • 2126.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • rat

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Citations

Mesenchymal Cells Appearing in Pancreatic Tissue Culture Are Bone Marrow-Derived Stem Cells With the Capacity to Improve Transplanted Islet Function.

Stemm Cells . 2010 Jan 01 ; 28(1) 140 | DOI : 10.1002/stem.259

  • V. Sordi

References

Digestive Function of the Stomach

Digestive Dis . 2014 Apr 10 ; 32(3) 186 | DOI : 10.1159/000357848.

  • A. O’Connor
  • et al

Gastrin: Old Hormone, New Functions

Pflügers Archiv . 2005 Jan 01 ; 449(4) 344 | DOI : 10.1007/s00424-004-1347-5

  • G. Dockray
  • et al

New Consensus Features for Tyrosine O-sulfation Determined by Mutational Analysis

JBC . 1997 Aug 29 ; 272(35) 21700 | DOI : 10.1074/jbc.272.35.21700.

  • JR. Bundgaard
  • et al

Ghrelin and Gastric Acid Secretion

World J Gastroenterol . 2008 Nov 07 ; 14(41) 6334 | DOI : 10.3748/wjg.14.6334.

  • K. Yakabi
  • et al

Hypergastrinemia--diagnosis and treatment.

Wien Klin Wochenschr . 2006 Dec 31 ; 119(19-20) 561 | DOI : 10.1007/s00508-007-0897-x.

  • B. Niederle

Unique Amino Terminal Structure of Rat Little Gastrin

Peptides . 1981 Oct 26 ; 2(4) 453 | DOI : 10.1016/s0196-9781(81)80104-0

  • JR. Reeve
  • et al

Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA

Peptides . 1982 Jul 08 ; 3(4) 693 | DOI : 10.1016/0196-9781(82)90172-3

  • MH. Schaffer
  • et al

Rat gastrin's amino acid sequence determined from the nucleotide sequence of the mRNA

Peptides . 1982 Jul 31 ; 3(4) 693 | DOI : https://doi.org/10.1016/0196-9781(82)90172-3

  • MH. Schaffer
  • et al