IMG-EN-AS-21791-01.jpg
Peptides

Beta-Amyloid (1-42) Peptide HCl salt

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  • Cat.Number : AS-21791
  • Availability :
    In stock

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. The HCl salt form of Aß (1-42) takes the ß-structure within a few hours in PBS and aggregates

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA • HCl
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH • HCl
CAS registry number
  • 107761-42-2
Molecular Formula
  • C203H311N55O60S
Molecular Mass/ Weight
  • 4514.4•36.5
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Microglial activation and amyloid-β clearance induced by exogenous heat-shock proteins.

FASEB J . 2002 Apr 01 ; 16(6) 601 | DOI : 10.1096/fj.01-0530fje.

  • J-I. Kakimura

Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with β-amyloid in rats.

Biol Pharm Bull . 2007 Apr 01 ; 30(4) 698 | DOI : 10.1248/bpb.30.698

  • K. Iwasaki

Cerebral ischemia combined with β-amyloid impairs spatial memory in the eight-arm radial maze task in rats.

Brain Res . 2006 May 26 ; 1097(1) 216 | DOI : 10.1016/j.brainres.2006.04.073.

  • K. Iwasaki

A novel neurotrophic agent, T-817MA [1-{3-[2-(1-Benzothiophen-5-yl) Ethoxy] Propyl}-3-azetidinol Maleate], attenuates amyloid-β-induced neurotoxicity and promotes neurite outgrowth in rat cultured central nervous system neurons.

JPET . 2005 Mar 29 ; 314(1) 252 | DOI : 10.1124/jpet.105.083543.

  • K. Hirata

Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats.

Neurotox Res . 2004 Jan 01 ; 6(4) 299 | DOI : 10.1007/bf03033440

  • K. Iwasaki

6-Ethyl-N,N'-bis(3-hydroxyphenyl)[1,3,5]triazine-2,4-diamine (RS-0466) enhances the protective effect of brain-derived neurotrophic factor on amyloid beta-induced cytotoxicity in cortical neurones.

Pharmacol Toxicol . 2003 Dec 01 ; 93(6) 264 | DOI : 10.1111/j.1600-0773.2003.pto930603.x.

  • T. Kubo

A novel compound RS-0466 reverses β-amyloid-induced cytotoxicity through the Akt signaling pathway in vitro.

Eur J Pharmacol . 2002 Dec 13 ; 457(1) 11 | DOI : 10.1016/s0014-2999(02)02657-2

  • Y. Nakagami

A novel β-sheet breaker, RS-0406, reverses amyloid β-induced cytotoxicity and impairment of long-term potentiation in vitro.

Br J Pharmacol . 2002 Oct 16 ; 137(5) 676 | DOI : 10.1038/sj.bjp.0704911.

  • Y. Nakagami