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Peptides

Bombesin - 1 mg

$55.00
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  • Cat.Number : AS-20665
  • Availability :
    In stock

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Bombesin is a 14-aa peptide originally isolated from the fire-bellied toad. It has two mammalian homologs, neuromedin and Gastrin-Releasing Peptide (GRP). It binds with high affinity to the GRP receptor, a member of the G-protein-coupled receptor family. It stimulates gastrin release from G cells, and acts in the brain to stop eating behavior.
Bombesin is also a tumor marker for lung small cell carcinoma, neuroblastoma, pancreatic cancer and gastric cancer.

Specifications

Chemistry
Sequence one letter code
  • Pyr-QRLGNQWAVGHLM-NH2
Sequence three letter code
  • Pyr-Gln-Arg-Leu-Gly-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2
CAS registry number
  • 31362-50-2
Molecular Formula
  • C71H110N24O18S
Molecular Mass/ Weight
  • 1620
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • toad

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Citations

A high-affinity near-infrared fluorescent probe to target bombesin receptors.

Mol Imaging Biol . 2014 Oct 01 ; 16(5) 661 | DOI : 10.1007/s11307-014-0727-2

  • A. Shrivastava

Heterobivalent dual-target probe for targeting GRP and Y1 receptors on tumor cells.

Bioorg Med Chem Lett . 2012 Dec 05 ; 23(3) 687 | DOI : 10.1016/j.bmcl.2012.11.110.

  • A. Shrivastava

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200

  • AJ. O'Donoghue

A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531

  • X. Zhao

References

Neuropeptides, antagonists and cell proliferation: bombesin as an example.

Cell Mol Biol . 1994 Aug 31 ; 40 731 | DOI : PMID: 7812181

  • JB. Dietrich
  • et al