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Peptides  >  Saposin Related Peptides  >>  Prosaptide TX14(A)

Product Name Prosaptide TX14(A)
Size 1 mg
Catalog # AS-60248-1
US$ $99
Purity % Peak Area By HPLC ≥ 95%

This 14-mer prosaptide sequence is derived from the active neurotrophic region in the amino-terminal portion of the saposin C domain. Synthetic peptides derived from this region are biologically active and are named “prosaptides.” Prosaposin and prosaptides are active on a variety of neuronal cells, stimulating sulfatide synthesis and increasing sulfatide concentration in Schwann cells and oligodendrocytes. This indicates that prosaposin and prosaptides are trophic factors for myelin formation.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References Campana, M. et al. FASEB J. 12, 307 (1998); Hiraiwa, M. et al. Proc. Natl. Acad. Sci. USA 94, 4778 (1997); Taylor, E. et al. Pharmacol. 295, 190 (2000); Calcutt, NA. et al. Anesthesiology 93, 1271 (2000).
Molecular Weight 1579.7
(One-Letter Code)
(Three-Letter Code)
H - Thr - D - Ala - Leu - Ile - Asp - Asn - Asn - Ala - Thr - Glu - Glu - Ile - Leu - Tyr - OH
Product Citations Meyer, R. et al. (2013). GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. PNAS 110, 9529. doi: 10.1073/pnas.1219004110.

Calcutt, NA. et al. (2004). Protection of sensory function and antihyperalgesic properties of a prosaposin-derived peptide in diabetic rats. Anesthesiol 93, 1271 (2000).

Otero, D. et al. (1999). Reversal of thermal hyperalgesia in a rat partial sciatic nerve ligation model by Prosaptide™ TX14(A). Neurosci Lett 270, 29.

Campana, WM. et al. (1998). Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 12, 307.

Hiraiwa, M. et al. (1997). Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. PNAS 94, 4778.
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