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Peptides  >  Pituitary Adenylate Cyclase Activating Peptides (PACAPS)  >>  PACAP (1-27), amide, human, ovine, rat

Product Name PACAP (1 - 27), amide, human, ovine, rat
Size 0.5 mg
Catalog # AS-22527
US$ $132
Purity % Peak Area By HPLC ≥ 95%

PACAP-27, the N-terminal fragment of PACAP-38, is a neuropeptide originally isolated from bovine hypothalamus, but is also found in humans and rats. It shows considerable homology with Vasoactive Intestinal Polypeptide (VIP), but stimulates adenylate cyclase much more potently than VIP. PACAP27 and PACAP38 stimulate cAMP accumulation and increase [Ca2+]i through the type I PACAP receptors.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Ref: Miyata, A. et al. BBRC 164, 567(1998); Chik, C. et al. J. Neurochem. 67, 1005 (1996).
Molecular Weight 3147.7
(One-Letter Code)
(Three-Letter Code)
H - His - Ser - Asp - Gly - Ile - Phe - Thr - Asp - Ser - Tyr - Ser - Arg - Tyr - Arg - Lys - Gln - Met - Ala - Val - Lys - Lys - Tyr - Leu - Ala - Ala - Val - Leu - NH2
Product Citations Kidane, A. et al. (2008). Pituitary adenylate cyclase-activating polypeptide regulates brain-derived neurotrophic factor exon IV expression through the VPAC1 receptor in the amphibian melanotrope cell. Endocrin. 149, 4177.

Kidane, A. et al. (2007). Actions of PACAP and VIP on melanotrope cells of Xenopus laevis. Peptides 28, 1790.

Wu, K. et al. (2006). Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones. Nat Neurosci 9, 1257.
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