IMG-EN-AS-22527-01.jpg
Peptides

PACAP (1-27), amide, human, ovine, rat - 0.5 mg

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  • Cat.Number : AS-22527
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PACAP-27, the N-terminal fragment of PACAP-38, is a neuropeptide originally isolated from bovine hypothalamus, but is also found in humans and rats. It shows considerable homology with Vasoactive Intestinal Polypeptide (VIP), but stimulates adenylate cyclase much more potently than VIP. PACAP27 and PACAP38 stimulate cAMP accumulation and increase [Ca2+]i through the type I PACAP receptors.

Specifications

Chemistry
Sequence one letter code
  • HSDGIFTDSYSRYRKQMAVKKYLAAVL-NH2
Sequence three letter code
  • H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-NH2
CAS registry number
  • 127317-03-7
Molecular Formula
  • C142H224N40O39S
Molecular Mass/ Weight
  • 3147.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human, ovine, rat

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Citations

Pituitary adenylate cyclase-activating polypeptide regulates brain-derived neurotrophic factor exon IV expression through the VPAC1 receptor in the amphibian melanotrope cell

Endocrinology . 2008 May 01 ; 149(8) 4177 | DOI : 10.1210/en.2008-0131

  • A. Kidane

Actions of PACAP and VIP on melanotrope cells of Xenopus laevis

Peptides . 2007 Mar 30 ; 28(9) 1790 | DOI : 10.1016/j.peptides.2007.03.013

  • A. Kidane

Soluble adenylyl cyclase is required for netrin-1 signaling in nerve growth cones

Nat Neurosci. . 2006 Sep 10 ; 9(10) 1257 | DOI : 10.1038/nn1767

  • K. Wu

References

Characterization of Pituitary Adenylate Cyclase-Activating Polypeptide 38 (PACAP38)-, PACAP27-, and Vasoactive Intestinal Peptide-Stimulated Responses in N1E-115 Neuroblastoma Cells

J Neurochem . 1996 Sep 01 ; 67(3) 1005 | DOI : https://doi.org/10.1046/j.1471-4159.1996.67031005.x

  • C. Chik
  • et al