IMG-EN-AS-22944-01.jpg
Peptides

[Thr28, Nle31]-Cholecystokinin (25-33), sulfated CCK-9 - 1 mg

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  • Cat.Number : AS-22944
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Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.
This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.

Specifications

Chemistry
Sequence one letter code
  • RD-Y(SO3H)-TGW-Nle-DF-NH2
Sequence three letter code
  • H-Arg-Asp-Tyr(SO3H)-Thr-Gly-Trp-Nle-Asp-Phe-NH2
CAS registry number
  • 77568-41-3
Molecular Formula
  • C55H74N14O18S
Molecular Mass/ Weight
  • 1251.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, mouse, rat

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References

Solution conformation of CCK9, a cholecystokinin analog.

Biochem Biophys Res Commun. . 1993 Feb 15 ; 190(3) 741 | DOI : 10.1006/bbrc.1993.1111

  • L. Moroder
  • et al