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Peptides

HIF-1a (556-574) - 1 mg

$164.00
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  • Cat.Number : AS-61528
  • Availability :
    In production

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This is a hypoxia-inducible factor-1 (HIF-1 a) 19-mer fragment. HIF-1 functions as a master regulator of response to oxygen homeostasis. Hypoxia-induced gene expression is initiated when HIF-1 subunit is stabilized in response to a lack of oxygen. This part of HIF-1 binds to the von Hippel-Lindau factor (VHL) an E3 ubiquitin ligase, and the proline 564 is absolutely critical to the binding process.

Specifications

Chemistry
Sequence one letter code
  • DLDLEMLAPYIPMDDDFQL
Sequence three letter code
  • H-Asp-Leu-Asp-Leu-Glu-Met-Leu-Ala-Pro-Tyr-Ile-Pro-Met-Asp-Asp-Asp-Phe-Gln-Leu-OH
Molecular Formula
  • C101H152N20O34S2
Molecular Mass/ Weight
  • 2254.7
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

J Biol Chem . 2003 Aug 01 ; 278(33) 30772 | DOI : https://doi.org/10.1074/jbc.M304982200

  • M. Hirsilä
  • et al

Much Huffing about HIF: Oxygen Dependent Proline Hydroxylation and the Regulation of Hypoxia Inducible Factors

Pediatric Research . 2001 Dec 01 ; 50(6) 673 | DOI : 10.1203/00006450-200112000-00003

  • B. Robinson