This is a 5-FAM-labeled Bid BH3 peptide. Bid is a pro-apoptotic member of the 'BH3-only' subset of the BCL-2 family proteins that constitute a critical control point in apoptosis. Bid interconnects extrinsic pathway TNFR1 and Fas death signals to the mitochondrial amplification of the intrinsic pathway. The references listed below belong to the unlabeled Bid BH3.
Oh, K. et al J. Biol. Chem. 280, 753 (2005); Oh, K. et al. J. Biol. Chem. 10.1074/jbc.M602341200 published ahead of print (2006); Manero, F. et al. Canc. Res. 66, 2757 (2006); Walensky, L. et al. Mol. Cell. 24, 199 (2006).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
5 - FAM - Glu - Asp - Ile - Ile - Arg - Asn - Ile - Ala - Arg - His - Leu - Ala - Gln - Val - Gly - Asp - Ser - Met - Asp - Arg - OH