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Peptides  >  Thrombin Related Peptides  >>  Protease-Activated Receptor-4, PAR-4 Agonist, amide, human

Product Name Protease - Activated Receptor - 4, PAR - 4 Agonist, amide, human
Size 1 mg
Catalog # AS-60779
US$ $55
Purity % Peak Area By HPLC ≥ 95%

This peptide is one of the four PAR sub-types, known to induce TNF-alpha secretion from HMC-1 (human leukemic mast cells). In smooth muscle cells, this peptide also induces a prolonged phosphorylation of ERK 1/2. PAR 4 is also known to induce scratching/itch via histamine involvement. PAR4 peptide is acted upon both by trypsin and thrombin. Co-expression of PAR3 and PAR4 enhances thrombin action. PAR4 is expressed in cutaneous mast cells of humans, but not expressed in either keratinocytes or primary afferents.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References 1, Tsujii, K. et al. J Pharmacol Sci. 108:385-388 (2008).
2, Kang, O-H, et al. 21:161-167 (2003).
Molecular Weight 618.7
(One-Letter Code)
(Three-Letter Code)
H - Gly - Tyr - Pro - Gly - Gln - Val - NH2
Product Citations Herve, Y. et al. (2012). The down regulation of neutrophil oxidative metabolism by S100A8 and S100A9: Implication of the protease-activated receptor-2. Mol Immunol50, 42. doi: 10.1016/j.molimm.2011.12.001.
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