IMG-EN-AS-62206-01.jpg
Peptides

Proapoptotic Peptide, (klaklak)2, 5-FAM-labeled - 1 mg

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  • Cat.Number : AS-62206
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This is the pro-apoptotic peptide composed of D-amino acids, 5-FAM labeled. This alpha-helical amphipathic peptide is toxic to eukaryotic cells if internalized by a suitable targeting mechanism. It disrupts mitochondrial membranes upon receptor-mediated cell internalization and causes programmed cell death.

Specifications

Chemistry
Sequence one letter code
  • 5-FAM-klaklakklaklak-NH2
Sequence three letter code
  • 5-FAM-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH2
Molecular Mass/ Weight
  • 1881.4
Properties
Absorbance (nm)
  • 492
Emission (nm)
  • 518
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use

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References

Selective Apoptotic Killing of Malignant Hemopoietic Cells by Antibody-Targeted Delivery of an Amphipathic Peptide

Cancer Res. . 2005 Mar 01 ; 65(6) 2373 | DOI : 10.1158/0008-5472.CAN-04-2594

  • A. Marks
  • et al

Reversal of obesity by targeted ablation of adipose tissue

Nat. Med. . 2004 May 09 ; 10(6) 625 | DOI : https://doi.org/10.1038/nm1048

  • M. Kolonin
  • et al