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Peptides  >  Histones  >  Histone H3 Peptides  >>  [Lys(Me2)4]-Histone H3 (1-21), H3K4(Me2)

Product Name [Lys(Me2)4] - Histone H3 (1 - 21), H3K4(Me2)
Size 1 mg
Catalog # AS-63677
US$ $225
Purity % Peak Area By HPLC ≥ 95%

This is a dimethylated lysine at position 4 of the 1-21 amino acid histone H3 peptide. This form of histone methylation is characterized as being enriched around transcription start sites (TSS). It has been observed that a subgroup of genes linked to T cell functions showed high levels of H3K4me2 within their gene body. While enrichment for H3K4me2 within the gene body is a characteristic trait of expressed genes in yeast, in contrast, H3K4me2 has been shown to be predominantly enriched around the TSS in mammals.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20C
References 1, Tian Y. et al. PLOS One. 6(11):e27770 (2011)
2, Pekowska A. et al. Genome Res. 20, 1493-1502 (2010).
Molecular Weight 2282.6
(One-Letter Code)
(Three-Letter Code)
H - Ala - Arg - Thr - Lys(Me2) - Gln - Thr - Ala - Arg - Lys - Ser - Thr - Gly - Gly - Lys - Ala - Pro - Arg - Lys - Gln - Leu - Ala - OH
Product Citations Sakane, C. et al. (2015). Measurement of lysine-specific demethylase-1 activity in the nuclear extracts by flow-injection based time-of-flight mass spectrometry. J Clin Biochem Nutr562:123-131. doi: 10.3164/jcbn.14-99.
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