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Peptides  >  Protein Phosphorylation Related Peptides  >>  Myristolated PKC Zeta, Pseudosubstrate (ZIP)

Product Name Myristolated PKC Zeta, Pseudosubstrate (ZIP)
Size 1 mg
Catalog # AS-63361
US$ $121
Purity % Peak Area By HPLC ≥ 95%

This is a myristoylated PKCζ pseudosubstrate-derived ζ-inhibitory peptide (ZIP) found to inhibit an atypical type of Protein Kinase C ζ (zeta). It has been shown to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. The pseudosubstrate peptide has also been shown to be a competitive inhibitor of PKCζ in neurons. This peptide was also used to demonstrate that PKC ζ is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils.

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
Storage -20°C
References 1, Bogard AS. and Tavalin JS. Mol Pharmacol, 88(4):728-735 (2015).
2, Yao Y. et al. Neuropharmacol, 64:37-44 (2013)
. 3, Dang P M-C. et al. J Immunol, 166(2):1206-1213 (2001)
Molecular Weight 1928.5
(One-Letter Code)
(Three-Letter Code)
Myr - Ser - Ile - Tyr - Arg - Arg - Gly - Ala - Arg - Arg - Trp - Arg - Lys - Leu - OH
Product Citations Bogard, A. S. et al. (2015). Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation. Mol Pharmcol doi: 10.1124/mol.115.099457.
Deng, Z. et al. (2015). Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach. Neurobiol Learning Memory 118, 89.
Kim, JV. et al. (2015). Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci 35, 6307. doi: 10.1523/JNEUROSCI.3481-14.2015.
Lu, R. et al. (2015). PKCι interacts with Rab14 and modulates epithelial barrier function through regulation of claudin-2 levels. Mol Biol Cell, mbc-E14. doi: 10.1091/mbc.E14-12-1613
Tillu, DV. et al. (2015). Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state Short Title: PAR2 activation causes chronic pain. Pain doi: 10.1097/j.pain.0000000000000125.
Li, Q. et al. (2014). Making synapses strong: metaplasticity prolongs associativity of long-term memory by switching synaptic tag mechanisms. Cereb Cortex 24, 353. doi: 10.1093/cercor/bhs315.
Vélez-Hernández, ME. et al. (2013). Inhibition of Protein kinase Mzeta (PKMζ) in the mesolimbic system alters cocaine sensitization in rats. J Drug Alcohol Res 2, 235669. doi: 10.4303/jdar/235669.
Yao, Y. et al. (2013). Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacol 64, 37.
Pauli, WM. et al. (2012). Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. 19, 307-314. doi:10.1101/lm.025148.111.
Wang, J. et al. (2012). Metabotropic actions of the volatile anaesthetic sevoflurane increase protein kinase Mζ synthesis and induce immediate preconditioning protection of rat hippocampal slices. J Physiol 590, 4093. doi: 10.1113/jphysiol.2012.233965.
Wu-Zhang, AX. et al. (2012). Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Its in Vitro Profile IMPLICATIONS FOR PKMζ AS A MEDIATOR OF MEMORY. J Biol Chem 287, 12879. doi: 10.1074/jbc.M112.357244.
Hardt, O. et al. (2010). PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus. Hippocampus 20, 691. doi: 10.1002/hipo.20708.
Migues, P. et al. (2010), PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci 13, 630. doi:10.1038/nn.2531.
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