Shepherdin (79–87) - 1 mg
- Cat.Number : AS-62748
- Manufacturer Ref. :
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This is amino acids 79 to 87 fragment of shepherdin, a peptidomimetic antagonist of the complex between Hsp90 and survivin, another key regulator of tumor cell viability. For its potent and broad antitumor activity, selectivity of action in tumor cells versus normal tissues, and inhibition of tumor growth in vivo without toxicity, shepherdin may offer a promising approach for rational cancer therapy. This sequence is also known as K79–K90.
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Citations
A Bombesin-Shepherdin radioconjugate designed for combined extra-and intracellular targeting
Pharmaceuticals (Basel). . 2014 May 27 ; 7(6) 662 | DOI : 10.3390/ph7060662
- CA. Fischer
References
Rational design of shepherdin, a novel anticancer agent
Cancer Cell . 2005 May 01 ; 7(5) 457 | DOI : https://doi.org/10.1016/j.ccr.2005.03.035
- J. Plescia
- et al