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Peptides  >  Protein Phosphorylation Related Peptides  >>  Myristolated PKC Zeta, Pseudosubstrate ZIP, Scrambled

Product Name Myristolated PKC Zeta, Pseudosubstrate ZIP, Scrambled
Size 1 mg
Catalog # AS-63695
US$ $121
Purity % Peak Area By HPLC ≥ 95%

This is a myristoylated peptide used as a control for the pseudosubstrate PKC Zeta. Scrambled ZIP has been used as a control for ZIP as it has identical amino acids as that of ZIP but in an altered sequence that decreases its efficacy by 3- to 4-fold. It has been used in studies to compare the effectiveness or activity of the pseudosubstrate.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References 1, Yao Y. et al. Neuropharmacol, 64:37-44 (2013).
2, Dang P M-C. et al. J Immunol, 166(2):1206-1213 (2001)
Molecular Weight 1928.5
(One-Letter Code)
(Three-Letter Code)
Myristoyl - Arg - Leu - Tyr - Arg - Lys - Arg - Ile - Trp - Arg - Ser - Ala - Gly - Arg - OH
Product Citations Bogard, A. S. et al. (2015). Protein kinase C (PKC)ζ pseudosubstrate inhibitor peptide promiscuously binds PKC family isoforms and disrupts conventional PKC targeting and translocation. Mol Pharmcol doi: 10.1124/mol.115.099457.

Deng, Z. et al. (2015). Zeta inhibitory peptide (ZIP) erases long-term memories in a cockroach. Neurobiol Learning Memory 118, 89.

Kim, JV. et al. (2015). Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism. J Neurosci 35, 6307. doi: 10.1523/JNEUROSCI.3481-14.2015.

Tillu, DV. et al. (2015). Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state Short Title: PAR2 activation causes chronic pain. Pain doi: 10.1097/j.pain.0000000000000125.

Yao, Y. et al. (2013). Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons. Neuropharmacol 64, 37.

Pauli, WM. et al. (2012). Inhibiting PKMζ reveals dorsal lateral and dorsal medial striatum store the different memories needed to support adaptive behavior. Learn Mem 19, 307. doi: 10.1101/lm.025148.111.

Wu-Zhang, AX. et al. (2012). Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Its in Vitro Profile IMPLICATIONS FOR PKMζ AS A MEDIATOR OF MEMORY. J Biol Chem 287, 12879. doi: 10.1074/jbc.M112.357244.

Hardt, O. et al. (2010). PKMζ maintains 1‐day‐and 6‐day‐old long‐term object location but not object identity memory in dorsal hippocampus. Hippocampus 20, 691. doi: 10.1002/hipo.20708.

Migues, P. et al. (2010), PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking. Nat Neurosci 13, 630.
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