Existing Account

Please login first to complete purchase/ quotation request, view custom order reports, or create favorites list.

Customer ID:
Stay Logged In

Forgot your Customer ID or Password?
New Account

Don't have an account with us yet? Please set up an account to place order or obtain customer services.

Peptides  >  Amyloid Peptides  >  Beta-Amyloid (1-28) and Related Peptides  >>  Beta-Amyloid (1-28), Human

Product Name Beta - Amyloid (1 - 28), Human
Size 1 mg
Catalog # AS-24232
US$ $186
Purity % Peak Area By HPLC ≥ 95%

The three-dimensional solution structure of A (1-28) reveals the folding of the peptide to form a predominantly a-helical structure with a bend centered at residue 12 and the side chains of histidine-13 and lysine-16 in close proximity, residing on the same face of the helix. Their proximity may constitute a binding motif with the heparan sulfate proteoglycans. A (1-28) is highly hydrophilic and shares sequences with bA4, the major component of A. Its assembly is fibrillar, i.e., elongated in a single direction. Reports show that synthetic peptides A (1-40) and A (1-28) have significant effects on normal human plasma cholesterol esterification rate. Both peptides (at concentration of 1 ng/mL) inhibit plasma cholesterol esterification rate by 40-50% compared to the control value.

Detailed Information Material Safety Data Sheets (MSDS)
Storage -20C
References Kirshenbaum K. and V. Daggett, Biochem. 34, 7640 (1995); Talafous, J. et al. Biochem. 33, 7788 (1994).
Molecular Weight 3262.7
(One-Letter Code)
(Three-Letter Code)
H - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - OH
Product Citations Hanenberg, M. et al. (2014). Amyloid-β peptide-specific DARPins as a novel class of potential therapeutics for Alzheimer Disease. J Biol Chem 289, 27080. doi: 10.1074/jbc.M114.564013.

Miles, L. A. et al. (2013). Bapineuzumab captures the N-terminus of the Alzheimer's disease amyloid-beta peptide in a helical conformation. Scientific Rpt 3. doi: 10.1038/srep01302.

Fukuyama, Y. et al. (2012). Alkylated dihydroxybenzoic acid as a MALDI matrix additive for hydrophobic peptide analysis. Anal Chem 84, 4237. doi: 10.1021/ac300540r.

Libeu, CP. et al. (2011). Structural and functional alterations in amyloid-β precursor protein induced by amyloid-β peptides. J Alzheimer's Dis 25, 547. doi: 10.3233/JAD-2011-101938.

Kanekiyo, T. et al. (2007). Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid. PNAS 104, 6412. doi: 10.1073/pnas.0701585104.

Atwood, C. et al. (2004). Copper mediates dityrosine cross-linking of Alzheimer's amyloid-β. Biochem 43, 560.

Ji, SR. et al. (2002). Cholesterol is an important factor affecting the membrane insertion of β-amyloid peptide (Aβ140), which may potentially inhibit the fibril formation. J Biol Chem 277, 6273. doi: 10.1074/jbc.M104146200.
  < Back