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Peptides  >  Histones  >  Histone H4 Peptides  >>  [Lys(Ac)16]-Histone H4 (1-21)-GGK(Biotin), H4K16(Ac), biotin-labeled

Product Name [Lys(Ac)16] - Histone H4 (1 - 21) - GGK(Biotin), H4K16(Ac), biotin - labeled
Size 1 mg
Catalog # AS-64847-1
US$ $269
Purity % Peak Area By HPLC ≥ 95%

This peptide is histone H4 amino acids 1 to 16, acetylated at Lys-16 and at the N-terminus. This peptide also contains a GG linker, followed by a biotinylated lysine. The acetylation of histone H4 causes structural changes that play a crucial role in amplifying the binding of transcription factors to specific recognition sites within the nucleosome.

Storage -20C
References Vettes-Dadey, M. et al. EMBO J 15, 10 (1996).
Molecular Weight 2644.1
(One-Letter Code)
(Three-Letter Code)
Ac - Ser - Gly - Arg - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys(Ac) - Arg - His - Arg - Lys - Val - Gly - Gly - Lys(Biotin) - OH
Product Citations Adhikary, S. et al. (2015). Selective recognition of H3.1K36 dimethylation/H4K16 acetylation facilitates the regulation of all-trans-retinoic acid (ATRA)-responsive genes by putative chromatin reader ZMYND8 J. Biol. Chem. 291 2664-2681 doi: 10.1074/jbc.M115.679985

Das, C. et al. (2014). Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation. PNAS 111, E1072. doi: 10.1073/pnas.1319122111.
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