[pThr11]-Histone H3 (1-21)-GGK(Biotin)-NH2 - 1 mg
- Cat.Number : AS-64973-1
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This peptide is histone H3 amino acid residues 1 to 21. It is phosphorylated at Thr-11 with a C-terminal GG linker, followed by a biotinylated lysine. The modification of Thr-11 via phosphorylation is processed by a number of enzymes, including protein kinase C-related kinase 1 (PRK1) and Serine/threonine-protein kinase Chk1. This has many important functions, such as the establishment of a novel chromatin marker for transcriptional regulation, and the regulation of DNA-damage induced transcriptional repression. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
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References
Chk1 Is a Histone H3 Threonine 11 Kinase that Regulates DNA Damage-Induced Transcriptional Repression
Cell . 2008 Jan 25 ; 132(2) 221 | DOI : https://doi.org/10.1016/j.cell.2007.12.013
- M. Shimada
- et al
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
Nat Cell Biol . 2007 Dec 09 ; 10(1) 53 | DOI : 10.1038/ncb1668
- E. Metzger
- et al