This peptide is histone H4 (1-23) asymmetrically dimethylated at Arg3 followed by a biotinylated Lys conjugated to a C-terminal GG linker. Methylation of Arg3 is catalyzed by PRMT1 and functions to promote p300 acetylation of histone H4. Dimethylation at Arg3 also activates transcription of estrogen-regulated genes. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.
Arita, K. et al. Proc Natl Acad Sci ,b>103, 5291 (2006); Wang, H. et al. Science293, 853 (2001).
Sequence (One-Letter Code)
Sequence (Three-Letter Code)
H - Ser - Gly - Arg(Me2a) - Gly - Lys - Gly - Gly - Lys - Gly - Leu - Gly - Lys - Gly - Gly - Ala - Lys - Arg - His - Arg - Lys - Val - Leu - Arg - Gly - Gly - Lys(Biotin) - OH