IMG-EN-AS-65411-1-01.jpg
Peptides

a-Tubulin (29-50) K40(Ac)-WGK, biotin - 1 mg

$417.00
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  • Cat.Number : AS-65411-1
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    In stock

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This is an acetylated alpha tubulin peptide at lysine 40 with a C-terminal WG linker followed by a biotinylated lysine. The acetylation at lysine 40 of this peptide is shown to have a therapeutic interest in diseases involving altered intracellular transport such as Huntington's disease. Histone Deacetylase (HDAC) inhibitors have been shown to increase vesicular transport of brain derived neurotrophic factor thereby increasing acetylation of tubulin at lysine 40.

Specifications

Chemistry
Sequence one letter code
  • Ac-GIQPDGQMPSD-K(ac)-TIGGGDDSFNWG-K(biotin)
Sequence three letter code
  • Ac-Gly-Ile-Gln-Pro-Asp-Gly-Gln-Met-Pro-Ser-Asp-- Lys(ac) -Thr-Ile-Gly-Gly-Gly-Asp-Asp-Ser-Phe-Asn-Trp-Gly-Lys(biotin)
Molecular Mass/ Weight
  • 2918.3
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Bovine

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References

Histone Deacetylase 6 Inhibition Compensates for the Transport Deficit in Huntington's Disease by Increasing Tubulin Acetylation

J Neurosci . 2007 Mar 28 ; 27(13) 3571 | DOI : https://doi.org/10.1523/JNEUROSCI.0037-07.2007

  • JP. Dompierre
  • et al