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Peptides  >  Cancer Research Peptides  >>  Human PD-L1 inhibitor I

Product Name Human PD - L1 inhibitor I
Size 1 mg
Catalog # AS-65581
US$ $160
Purity Peak Area by HPLC ≥95%

Programed cell death protein 1 (PD-1) is a cell surface receptor. PD-1 and its ligand PD-L1 are crucial immune checkpoints to downregulate T cell activation, tolerance and immunopathology. Several types of cancer cells overexpress PD-L1 in order to escape from the PD-1/PD-L1 immunosurveillance mechanism.
Human PD-L1 inhibitor I is a peptide-based molecule. It binds to human PD-1 and inhibits PD-1/PD-L1 binding. This peptide, PDL-1 inhibitor I has anchor residues, WDY that influence binding of hPD-L1 to hPD-1. Developing inhibitors specifically blocking the PD-1/PD-L1 pathway has become a popular approach toward cancer treatment.

PD-L1 Related Peptides:
Human PD-L1 inhibitor II, Cat# AS-65582
Human PD-L1 inhibitor III, Cat# AS-65583
Human PD-L1 inhibitor IV, Cat# AS-65584
Human PD-L1 inhibitor V, Cat# AS-65585

Detailed Information Datasheet
Material Safety Data Sheets (MSDS)
References Bardhan K., et.al, Front Immunol 7(550), (2016); Li Q., et.al, Oncotarget 7(40), 64967-64976 (2016); D'Errico G., et.al, Clin Transl Med 6(1), 3-12 (2017)
Molecular Weight 2350.7
(One-Letter Code)
(Three-Letter Code)
H - Phe - Asn - Trp - Asp - Tyr - Ser - Trp - Lys - Ser - Glu - Arg - Leu - Lys - Glu - Ala - Tyr - Asp - Leu - OH
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