This is a fluorescent (HiLexa™ Fluor 488) labeled ß-Amyloid peptide, Abs/Em=503/528 nm. HiLexa 488™ Fluor labeled Aß (1-42) offers brighter intensity with high fluorescence quantum yield and photostability suitable for pH-insensitive applications including flow cytometry and imaging. HiLexa™ Fluor 488 has the same structure as that of Alexa® Fluor 488. Aß (1-42), a major component of amyloid plaques and accumulates in neurons of Alzheimer’s disease (AD) brains. Solvent Information
HiLexa™ Fluor 488 labeled ß-Amyloid peptide can be used in studies applicable for monitoring aggregation kinetics of Aβ via steady-state fluorescence, measuring amyloid aggregates in cellular compartments in live neurons via confocal microscopy, quantification of Aβ(1-42) by flow cytometry upon cellular uptake, monitoring Aβ fibrillogenesis via fluorescence correlation spectroscopy, assaying Aβ degradation, evaluating role of autophagy in cell lines via immunoblotting, in vitro phagocytosis assay to determine uptake efficacy by macrophages, and a host of other applications including immunocytochemistry, RT-PCR etc.
HiLexa™ Fluor488 - Asp - Ala - Glu - Phe - Arg - His - Asp - Ser - Gly - Tyr - Glu - Val - His - His - Gln - Lys - Leu - Val - Phe - Phe - Ala - Glu - Asp - Val - Gly - Ser - Asn - Lys - Gly - Ala - Ile - Ile - Gly - Leu - Met - Val - Gly - Gly - Val - Val - Ile - Ala - OH