Peptides

ACTH (18-39), human (CLIP) - 1 mg

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  • Cat.Number : AS-20619
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This ACTH (18-39) fragment is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine.

Specifications

Chemistry
Sequence one letter code
  • RPVKVYPNGAEDESAEAFPLEF
Sequence three letter code
  • H-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
CAS registry number
  • 53917-42-3
Molecular Formula
  • C112H165N27O36
Molecular Mass/ Weight
  • 2465.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Elucidation of thioredoxin target protein networks in mouse.

Mol. Cell. Proteomics . 2009 May 04 ; 8(7) 1674 | DOI : 10.1074/mcp.M800580-MCP200

  • C. Fu

Inhibition of a secreted glutamic peptidase prevents growth of the fungus Talaromyces emersonii

J Biol Chem. . 2008 Aug 07 ; 283(43) 29186 | DOI : 10.1074/jbc.M802366200

  • AJ. O'Donoghue

A homogeneous enzyme fragment complementation-based β-arrestin translocation assay for high-throughput screening of G-protein-coupled receptors

J Biomol Screen. . 2008 Jul 25 ; 13(8) 737 | DOI : 10.1177/1087057108321531

  • X. Zhao

References

CORTICOTROPHIN-LIKE PEPTIDES IN THE RAT PITUITARY

J Endocrinol . 1974 Jun 01 ; 61(3) 355 | DOI : https://doi.org/10.1677/joe.0.0610355

  • AP. Scott
  • et al

Effect of corticotropin-like intermediate lobe peptide on pancreatic exocrine function in isolated rat pancreatic lobules

J Clin Invest . 1984 Nov 01 ; 74(5) 1886 | DOI : 10.1172/JCI111608

  • JB. Marshall
  • et al

Identification of beta-cell-trophin, a peptide of the pituitary pars intermedia which stimulates insulin secretion in plasma from genetically obese (ob/ob) mice

J Endocrinol . 1982 Jul 01 ; 94(1) 125 | DOI : https://doi.org/10.1677/joe.0.0940125

  • NA. Bellingham
  • et al

Immunohistochemical distribution of corticotropin-like intermediate lobe peptide (CLIP) immunoreactivity in the human brain

Brain Res Bull . 1991 Jan 01 ; 26(1) 99 | DOI : https://doi.org/10.1016/0361-9230(91)90194-O

  • A. Zaphiropoulos
  • et al