IMG-EN-AS-72216-01.jpg
Peptides

AggreSure ß-Amyloid (1-42), human - 0.25 mg

$346.00
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  • Cat.Number : AS-72216
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    In stock
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AggreSure beta-Amyloid (1-42) peptide is pretreated and tested for aggregation using SensoLyte® ThT Aβ42 Aggregation kit (Cat# AS-72214). Aggregation is guaranteed. The quantity is 0.25mg net peptide.

Alzheimer's Disease (AD) is the most common neurodegenerative disorder in elderly people. It has been demonstrated that AD has biological causes and is characterized by the presence of senile plaques and neurofibrillary tangles mainly in cerebral cortex and hippocampus brain regions. Beta-Amyloid (1-40) (Aβ40) and beta-Amyloid (1-42) (Aβ42) are the main components of the above plaques; however, other forms of beta-Amyloid peptides are also present. Both peptides are cleaved from the Amyloid Precursor Protein (APP) by β-secretase and ?-secretase enzymes. Many studies suggest that Aβ42 or/and Aβ43 are required to initiate formation of amyloid plaques and neurofibrills that leads to the neurodegeneration, while Aβ40 is less neurotoxic.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 107761-42-2
UniProt number
  • P05067
Molecular Formula
  • C203H311N55O60S
Molecular Mass/ Weight
  • 4514.4
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Resuspension condition
  • Reconstitute peptide in either 50mM Tris/150mM NaCl (pH 7.2) or 20mM HEPES/150mM NaCl (pH 7.2) at 0.25 mg/ml. Use water bath sonicator to completely dissolve peptide if necessary. Do not vortex!
Storage Conditions
  • Store at -20°C. Do not freeze-thaw reconstituted peptide.
Activity
Application
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Differential vulnerability of hippocampal CA3-CA1 synapses to Aβ

Acta Neuropathologica Communications . 2022 Apr 04 ; 10 45 | DOI : https://doi.org/10.1186/s40478-022-01350-7

  • OA Shipton
  • et al

Pandanus amaryllifolius Exhibits In Vitro Anti-Amyloidogenic Activity and Promotes Neuroprotective Effects in Amyloid-βInduced SH-SY5Y Cells

Nutrients . 2022 Sep 24 ; 14(19) 3962 | DOI : https://doi.org/10.3390/nu14193962

  • MA Tan
  • et al

Amyloid beta and its naturally occurring N-terminal variants are potent activators of human and mouse formyl peptide receptor 1

J. Biol. Chem. . 2022 Oct 27 ; 102642 | DOI : https://doi.org/10.1016/j.jbc.2022.102642

  • L. Busch
  • et al

Synapsin Condensates Recruit alpha-Synuclein

J Molec Biol . 2021 Jun 11 ; 433(12) 166961 | DOI : https://doi.org/10.1016/j.jmb.2021.166961

  • C. Hoffmann
  • et al

Fas Apoptosis Inhibitory Molecule Blocks and Dissolves Pathological Amyloid-β Species

Front Mol Neurosci . 2021 Dec 14 ; 14 750578 | DOI : 10.3389/fnmol.2021.750578

  • H. Kaku
  • et al

Troxerutin flavonoid has neuroprotective properties and increases neurite outgrowth and migration of neural stem cells from the subventricular zone

PLoS One . 2020 Aug 14 ; 15(8) e0237025 | DOI : https://doi.org/10.1371/journal.pone.0237025

  • MI Masood
  • et al

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

J. Biol. Chem. . 2018 Aug 01 ; 293(32) 12620 | DOI : https://doi.org/10.1074/jbc.RA118.001848

  • Q Cheng
  • et al

Experimental Analysis of Interacting HT22 Plasma Membrane Cholesterol and β-Amyloid

Advances in Alzheimer’s Disease . 2017 Dec 25 ; 6 75 | DOI : 10.4236/aad.2017.64006

  • G. Livadiotis
  • et al

Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42

Alzheimer's Research & Therapy . 2017 Oct 17 ; 9 86 | DOI : 10.1186/s13195-017-0310-6

  • S. An
  • et al

Oligomeric forms of amyloid-β protein in plasma as a potential blood-based biomarker for Alzheimer’s disease

Alzheimer's Research & Therapy . 2017 Dec 15 ; 9 98 | DOI : 10.1186/s13195-017-0324-0

  • M-J. Wang,
  • et al

References

Cobalt(III) Schiff base complexes stabilize non-fibrillar amyloid-β aggregates with reduced toxicity

J Inorg Biochem . 2021 Dec 01 ; 213 111265 | DOI : https://doi.org/10.1016/j.jinorgbio.2020.111265

  • KF Roberts
  • et al