Amylin (8-37), rat, mouse - 1 mg
- Cat.Number : AS-21749
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This is a truncated peptide of native rat amylin. In-vivo and in-vitro studies suggest that it acts as a specific amylin antagonist. In isolated soleus muscle, it blocks amylin-induced inhibition of glycogen synthesis but has no effect in the absence of amylin. Amylin (8-37) increases whole body and muscle insulin sensitivity and consistently reduces basal insulin levels in normal and hGH-induced insulin-resistant rats. It also elicits a significant alteration of in-vivo lipid metabolism.
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References
Amylin or CGRP (8–37) fragments reverse amylin-induced inhibition of 14C-glycogen accumulation
Biochem Biophys Res Commun . 1991 Nov 27 ; 181(1) 116 | DOI : https://doi.org/10.1016/S0006-291X(05)81389-0
- RO. Deems
- et al
Rat amylin-(8—37) enhances insulin action and alters lipid metabolism in normal and insulin-resistant rats
J Physiol Endocrinol Metab . 1997 Nov 01 ; 273(5) E859 | DOI : https://doi.org/10.1152/ajpendo.1997.273.5.E859
- M. Hettiarachchi
- et al