Peptides

Insulin B (9-23) - 1 mg

$124.00
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  • Cat.Number : AS-61532
  • Availability :
    In stock

Quantity

This insulin B-chain peptide binds to a class II histocompatibility complex (MHC) allele called I-Ag7. A number of autoimmune diseases has been linked to class II proteins encoded by the MHC. Type 1 diabetes, or insulin-dependent diabetes mellitus, is a T cell-mediated disease that results in autoimmune destruction of pancreatic ß cells leading to hyperglycemia. This insulin B peptide may be a self-antigen candidate that could initiate the disease. Immunization with this peptide in mice led to autoantibodies and insulitis.

Specifications

Chemistry
Sequence one letter code
  • SHLVEALYLVCGERG
Sequence three letter code
  • H-Ser-His-Leu-Val-Glu-Ala-Leu-Tyr-Leu-Val-Cys-Gly-Glu-Arg-Gly-OH
Molecular Formula
  • C72H116N20O22S
Molecular Mass/ Weight
  • 1646
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • pig

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Citations

Cutting Edge: immunosuppressant as adjuvant for tolerogenic immunization

J Immunol. . 2008 Apr 15 ; 180(8) 5172 | DOI : 10.4049/jimmunol.180.8.5172

  • Y. Kang

Enhanced trafficking to the pancreatic lymph nodes and auto-antigen presentation capacity distinguishes peritoneal B lymphocytes in non-obese diabetic mice.

Diabetologia . 2009 Nov 22 ; 53(2) 346 | DOI : 10.1007/s00125-009-1599-x

  • S. Alam

Inflammatory Tendencies and overproduction of IL-17 in the colon of young NOD mice are counteracted with diet change.

Diabetes . 2010 Jun 14 ; 59(9) 2237 | DOI : 10.2337/db10-0147

  • C. Alam

References

Directed evolution of a single-chain class II MHC product by yeast display

Protein Eng . 2003 Feb 01 ; 16(2) 147 | DOI : https://doi.org/10.1093/proeng/gzg018

  • S. Starwalt
  • et al

Interferon-α as a Mediator of Polyinosinic:Polycytidylic Acid–Induced Type 1 Diabetes

Diabetes . 2005 Sep 01 ; 54(9) 2549 | DOI : https://doi.org/10.2337/diabetes.54.9.2549

  • D. Devendra
  • et al

The role of TNF-α in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation

PNAS . 2005 Nov 01 ; 102(44) 15995 | DOI : https://doi.org/10.1073/pnas.0508122102

  • L. Lee
  • et al