IMG-EN-AS-65261-1-01.jpg
Peptides

[Arg(Me2a)26]-Histone H3 (15-36)-GGK(Biotin) - 1 mg

$452.00
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  • Cat.Number : AS-65261-1
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    In stock

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This peptide is histone H3 (15-36) asymmetrically dimethylated at Arg26, followed by a C-terminal GGK with biotinylation on the side chain of Lys. Dimethylation at Arg26 is catalyzed by CARM1 and inhibits deimination by peptidylarginine deiminase (PADI)-4. Arginine methylation of histone H3 is associated with transcriptional activation. Provided at >95% peptide purity, this peptide was dissolved in distilled water at 1 mg/ml and re-lyophilized to powder form.

Specifications

Chemistry
Sequence one letter code
  • APRKQLATKAA-R(Me2a)-KSAPATGGVK-GGK(Biotin)
Sequence three letter code
  • H-Ala-Pro-Arg-Lys-Gln-Leu-Ala-Thr-Lys-Ala-Ala-Arg(Me2a)-Lys-Ser-Ala-Pro-Ala-Thr-Gly-Gly-Val-Lys-Gly-Gly-Lys(Biotin)-OH
Molecular Mass/ Weight
  • 2704.4
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

PELP1 oncogenic functions involve CARM1 regulation.

Carcinogenesis . 2013 Mar 13 ; 34(7) 1468 | DOI : 10.1093/carcin/bgt091

  • M. Mann

References

Histone Deimination Antagonizes Arginine Methylation

Cell . 2004 Sep 03 ; 118(5) 545 | DOI : https://doi.org/10.1016/j.cell.2004.08.020

  • G. Cuthbert
  • et al