Peptides

Beta-Amyloid (1-16) Peptide

  • Cat.Number : AS-24225
  • Availability :
    In production

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Proteins interactions with reactive oxygen agents may result in covalent modifications of amino acid residues in proteins, formation of protein-protein cross-linkages and oxidation of the protein backbone resulting in protein fragmentation. Oxidation targets for Aß(1-16) are the histidine residues coordinated to the metal ions. Copper is bound to Aß in senile plaque of Alzheimer’s disease with Aß (1-16) taking part in the coordination of the Cu2+ ions. Cu2+ and Zn2+ are linked with the neurotoxicity of Aß and free radical damage.

Specifications

Chemistry
Sequence one letter code
  • DAEFRHDSGYEVHHQK
Sequence three letter code
  • H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH
CAS registry number
  • 131580-10-4
Molecular Formula
  • C84H119N27O28
Molecular Mass/ Weight
  • 1955.1
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Beta-Amyloid (1-42)

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Citations

CLAC Binds to Amyloid β Peptides through the Positively Charged Amino Acid Cluster within the Collagenous Domain 1 and Inhibits Formation of Amyloid Fibrils

JBC . 2004 Dec 21 ; 280 15484 | DOI : 10.1074/jbc.M413340200

  • Y. Osada

Identifying the minimal copper- and zinc-binding site sequence in amyloid-β peptides

J Biol Chem . 2008 Jan 30 ; 283(16) 10784 | DOI : 10.1074/jbc.M707109200

  • V. Minicozzi

Rapid method for measurement of surface tension in multiwell plates

Lab Invest. . 2004 Jan 19 ; 84(4) 523 | DOI : 10.1038/labinvest.3700054

  • MG. Cottingham

Behavior of β-amyloid 1-16 at the air-water interface at varying pH by nonlinear spectroscopy and molecular dynamics simulations.

J Phys Chem . 2011 Mar 17 ; 115(23) 5873 | DOI : 10.1021/jp110103j.

  • A. Miller

Identifying the minimal Cu and Zn binding site sequence in amyloid beta peptides.

J Biol Chem . 2008 Jan 30 ; 283(16) 10784 | DOI : 10.1074/jbc.M707109200.

  • V. Minicozzi

References

Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42

Molecular Immuno . 2008 Feb 01 ; 45(4) 881 | DOI : https://doi.org/10.1016/j.molimm.2007.08.008

  • RS. Solorzano-Vargas

Catechol Oxidase-like Oxidation Chemistry of the 1–20 and 1–16 Fragments of Alzheimer's Disease-related β-Amyloid Peptide THEIR STRUCTURE-ACTIVITY CORRELATION AND THE FATE OF HYDROGEN PEROXIDE

J Biol Chem . 2005 Apr 01 ; 280(17) 16601 | DOI : https://doi.org/10.1074/jbc.M411533200

  • GFZ. Da Silva
  • et al

Coordination abilities of the 1–16 and 1–28 fragments of β-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study

J Inorg Biochem . 2003 Jul 01 ; 95(4) 270 | DOI : https://doi.org/10.1016/S0162-0134(03)00128-4

  • T. Kowalik-Jankowska
  • et al

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1–10, 1–16 fragments of human and mouse β-amyloid peptide

J Inorg Biochem . 2004 Jul 01 ; 98(6) 940 | DOI : https://doi.org/10.1016/j.jinorgbio.2004.03.001

  • T. Kowalik-Jankowska
  • et al