IMG-EN-AS-23526-01-01.jpg
Peptides

Beta-Amyloid (1-42), FAM-labeled

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  • Cat.Number : AS-23526-01
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    In stock

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This is a fluorescent (FAM)-labeled ß-Amyloid peptide, Abs/Em=494/521 nm.

Specifications

Chemistry
Sequence one letter code
  • FAM-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • FAM-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 1802087-78-0
Molecular Formula
  • C224H321N55O66S
Molecular Mass/ Weight
  • 4872.7
Properties
Absorbance (nm)
  • 494
Emission (nm)
  • 521
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

J Neurosci . 2009 Mar 18 ; 29(11) 3603 | DOI : https://doi.org/10.1523/JNEUROSCI.5302-08.2009

  • L. Zhao

Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides (i).

J Neuroinflammation. . 2010 Oct 11 ; 7 61 | DOI : 10.1186/1742-2094-7-61

  • S. Fleisher-Berkovich

Preferential accumulation of Aβ(1−42) on gel phase domains of lipid bilayers: An AFM and fluorescence study

Biochim Biophys Acta. . 2007 Jan 01 ; 1768(1) 146 | DOI : 10.1016/j.bbamem.2006.09.005

  • A. Choucair

Internalization of β-amyloid peptide by primary neurons in the absence of apolipoprotein E

J Biol Chem. . 2007 Dec 07 ; 282(49) 35722 | DOI : 10.1074/jbc.M701823200

  • L. Saavedra

Alzheimer's β-peptide oligomer formation at physiologic concentrations

Anal Biochem. . 2004 Dec 01 ; 335(1) 81 | DOI : 10.1016/j.ab.2004.08.014

  • H. LeVine

References

β-Amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment

Eur. J. Pharmacol. . 2000 Mar 31 ; 392(3) 117 | DOI : https://doi.org/10.1016/S0014-2999(00)00127-8

  • H. Wei
  • et al