Peptides

Beta-Amyloid (1-42), TAMRA-labeled - 0.1 mg

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  • Cat.Number : AS-60476
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    In stock

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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide is labeled with TAMRA, Abs/Em = 544/572 nm

Specifications

Chemistry
Sequence one letter code
  • TAMRA-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • TAMRA-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 1802087-80-4
Molecular Formula
  • C228H331N57O64S
Molecular Mass/ Weight
  • 4926.9
Properties
Absorbance (nm)
  • 544
Emission (nm)
  • 572
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Two-Photon and Time-Resolved Fluorescence Conformational Studies of Aggregation in Amyloid Peptides

J Phy CehmB . 2010 Apr 29 ; 114 7112 | DOI : https://doi.org/10.1021/jp101496y

  • Y. Wang
  • et al

A novel Aβ-fibrinogen interaction inhibitor rescues altered thrombosis and cognitive decline in Alzheimer’s disease mice.

J Exp Med . 2014 May 12 ; 211(6) 1049 | DOI : 10.1084/jem.20131751.

  • HJ. Ahn
  • et al

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance.

Neurobiol Disease . 2014 Jan 09 ; 65 82 | DOI : 10.1016/j.nbd.2013.12.019.

  • J. Domert
  • et al

K114 Inhibits A-beta Aggregation and Inflammation In Vitro and In Vivo in AD/Tg Mice.

Curr Alzheimer Res . 2014 Mar 01 ; 11(3) 299 | DOI : 10.2174/1567205011666140220125324

  • YH. Zhang
  • et al

Spreading of neurodegenerative pathology via neuron-to-neuron transmission of β-amyloid

J Neurosci. . 2012 Jun 27 ; 32(26) 8767 | DOI : 10.1523/JNEUROSCI.0615-12.2012

  • S. Nath
  • et al