Beta-Amyloid (1-9) - 1 mg
- Cat.Number : AS-61970
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This is the N-terminal fragment of b-Amyloid peptide amino acids 1 to 9. Omission of residues 1 to 9 from the full-length Alzheimer's b-Amyloid peptide 1 to 40 does not prevent the peptide from forming amyloid fibrils or eliminate fibril polymorphism. This b-Amyloid peptide fragment contains a functional B cell epitope, but lacks known T cell epitopes, which makes it an attractive candidate for the development of b-Amyloid vaccine that lacks the potential to induce autoimmune encephalitis.
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References
Papillomavirus-Like Particles Are an Effective Platform for Amyloid-β Immunization in Rabbits and Transgenic Mice
J Immunol . 2006 Aug 15 ; 177(4) 2662 | DOI : https://doi.org/10.4049/jimmunol.177.4.2662
- E. Zamora
- et al
Polymorphic Fibril Formation by Residues 10–40 of the Alzheimer’s β-Amyloid Peptide
Biophys J . 2006 Jun 15 ; 90(12) 4618 | DOI : https://doi.org/10.1529/biophysj.105.076927
- A. Paravastu
- et al