IMG-EN-AS-63327-01.jpg
Peptides

Beta-Amyloid (11-42), HiLyte™ Fluor 488-labeled - 0.1 mg

$232.00
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  • Cat.Number : AS-63327
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This is amino acids 11 to 42 fragment of β-amyloid peptide labeled with HiLyte™ Fluor 488, Abs/Em=503/528 nm. Post-mortem Alzheimer’s diseased (AD) brain specimens reveal significant levels of this β-amyloid peptide within the insoluble amyloid pools. HiLyte™ Fluor 488-labeled b-amyloid (11-42) has a brighter intensity than FITC or FAM-labeled b-amyloid (11-42).

Specifications

Chemistry
Sequence one letter code
  • HiLyte™ Fluor 488-EVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • Hilyte™ Fluor 488-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
Molecular Mass/ Weight
  • 3692.5
Properties
Absorbance (nm)
  • 503
Emission (nm)
  • 528
Modification
Conjugation type
  • Fluorescent dyes
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C Protected from light
Activity
Biomarker Target
Detection Method
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

β-Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer’s Disease Brain

J Biol Chem . 2002 May 01 ; 277(18) 16278 | DOI : https://doi.org/10.1074/jbc.M111141200

  • J.T. Huse
  • et al

Glu11 Site Cleavage and N-Terminally Truncated Aβ Production upon BACE Overexpression

Biochem . 2002 Feb 08 ; 41(9) 3128 | DOI : https://doi.org/10.1021/bi015800g

  • K. Liu
  • et al

Processing Amyloid Precursor Protein at the β-Site Requires Proper Orientation to Be Accessed by BACE1

J Biol Chem . 2004 Sep 01 ; 279(37) 3910 | DOI : https://doi.org/10.1074/jbc.M407101200

  • I. Qahwash
  • et al