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Peptides

Beta-Amyloid (3-16) - 1 mg

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  • Cat.Number : AS-64793
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This peptide is amino acids 3 to 16 fragment of beta-Amyloid (Aß) with an N-terminal deletion that alters the coordination environment for the Cu2+ binding site. Oxidation targets for Aß (1-16) are the histidine residues coordinated to the metal ions.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.

Specifications

Chemistry
Sequence one letter code
  • EFRHDSGYEVHHQK
Sequence three letter code
  • H-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-OH
Molecular Formula
  • C77H109N25O24
Molecular Mass/ Weight
  • 1769
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Catechol Oxidase-like Oxidation Chemistry of the 1–20 and 1–16 Fragments of Alzheimer's Disease-related β-Amyloid Peptide THEIR STRUCTURE-ACTIVITY CORRELATION AND THE FATE OF HYDROGEN PEROXIDE

J Biol Chem . 2005 Apr 01 ; 280(17) 16601 | DOI : https://doi.org/10.1074/jbc.M411533200

  • GFZ. Da Silva
  • et al

Coordination abilities of the 1–16 and 1–28 fragments of β-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study

J Inorg Biochem . 2003 Jul 01 ; 95(4) 270 | DOI : https://doi.org/10.1016/S0162-0134(03)00128-4

  • T. Kowalik-Jankowska
  • et al

N-Terminal Deletions Modify the Cu2+ Binding Site in Amyloid-β

Biochem . 2005 Jan 01 ; 44(14) 5478 | DOI : https://doi.org/10.1021/bi047611e

  • J. Karr
  • et al

Products of Cu(II)-catalyzed oxidation in the presence of hydrogen peroxide of the 1–10, 1–16 fragments of human and mouse β-amyloid peptide

J Inorg Biochem . 2004 Jul 01 ; 98(6) 940 | DOI : https://doi.org/10.1016/j.jinorgbio.2004.03.001

  • T. Kowalik-Jankowska
  • et al