Beta-Amyloid A4 Protein Precursor (740-770), APP (C31) - 1 mg
- Cat.Number : AS-62073
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This 31-amino acid peptide C31 corresponds to the C-terminal fragment of the Amyloid Precursor Protein (APP). Caspase cleavage of amyloid beta-protein precursor with the generation of C31 may be involved in the neuronal death associated with Alzheimer disease. The resultant C31 peptide is a potent inducer of apoptosis. This peptide is located in lipid rafts together with the APP-BP1, a binding protein for the intracellular domain of APP.
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References
A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
Nat Med . 2000 Apr 01 ; 6(4) 397 | DOI : 10.1038/74656
- D. Lu
- et al
APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain
J Cell Biol . 2003 Oct 13 ; 163(1) 27 | DOI : https://doi.org/10.1083/jcb.200304003
- Y. Chen
- et al