IMG-EN-AS-23968-01.jpg
Peptides

Biotin-ACTH (1-39), human - 0.5 mg

$276.00
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  • Cat.Number : AS-23968
  • Availability :
    In stock

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This C-terminally labeled biotin ACTH (1-39) has been used in ELISA assays. Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a cleavage product from a larger precursor proopiomelanocortin (POMC). This 39 amino acid-peptide hormone is produced in the anterior pituitary gland upon stimulation by the corticotropin releasing hormone from the hypothalamus in response to stress. It stimulates the secretion of steroid hormone, specifically glucocorticoids in the adrenal cortex by acting through a cell membrane receptor (ACTH-R). In mammals, the action of ACTH is limited to those areas of the adrenal cortex in which the glucocorticoid hormones cortisol (hydrocortisone) and corticosterone are formed. ACTH has little control over the secretion of aldosterone, the other major steroid hormone from the adrenal cortex.

Specifications

Chemistry
Sequence one letter code
  • Biotin-SYSMEHFRWGKPVGKKRRPVKVYPNGAEDESAEAFPLEF
Sequence three letter code
  • Biotin-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH
CAS registry number
  • 1816258-26-0
Molecular Formula
  • C217H322N58O60S2
Molecular Mass/ Weight
  • 4767.6
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Ultrasensitive detection of adrenocorticotropin hormone (ACTH) using disposable phenylboronic-modified electrochemical immunosensors.

Biosensors Bioelectronics . 2012 May 15 ; 35(1) 82 | DOI : 10.1016/j.bios.2012.02.015.

  • M. Moreno-Guzmán

References

ACTH precursors characterize the ectopic ACTH syndrome

Clin Endocrinol . 1994 Feb 01 ; 40(2) 199 | DOI : 10.1111/j.1365-2265.1994.tb02468.x

  • PM. Stewart
  • et al

The expression of the ACTH recepto

Braz J Med Biol Res . 2000 Oct 01 ; 33(10) 1245 | DOI : https://doi.org/10.1590/S0100-879X2000001000015

  • LL. Elias
  • AJ. Clark

Role of ACTH receptor in adrenocortical tumor formation

Braz J Med Biol Res . 2000 Sep 22 ; 33(10) 1249 | DOI : https://doi.org/10.1590/S0100-879X2000001000016

  • AC. Latronico