Peptides

Biotin-beta-Amyloid (1-42)

  • Cat.Number : AS-23524-01
  • Availability :
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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide is biotinylated at the N-terminus.

Specifications

Chemistry
Sequence one letter code
  • Biotin-DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Sequence three letter code
  • Biotin-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH
CAS registry number
  • 102577-21-9
Molecular Formula
  • C213H325N57O62S2
Molecular Mass/ Weight
  • 4740.7
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • ≥ 95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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Citations

Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines

PLoS One . 2015 Jan 22 ; 10(1) e0115237 | DOI : 10.1371/journal.pone.0115237

  • M. Mandler
  • et al

Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome

Neurosci Lett . 2010 Feb 05 ; 470(1) 81 | DOI : https://doi.org/10.1016/j.neulet.2009.12.062

  • C. Arriagada
  • et al

Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism

J Neurosci . 2009 Mar 18 ; 29(11) 3603 | DOI : https://doi.org/10.1523/JNEUROSCI.5302-08.2009

  • L. Zhao
  • et al

Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)

Neurochem Int . 2008 May 01 ; 52(6) 1030 | DOI : https://doi.org/10.1016/j.neuint.2007.10.020

  • G. Gevorkian
  • et al

Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.

J Neurosci . 2009 Sep 02 ; 29(35) 10961 | DOI : 10.1523/JNEUROSCI.6088-08.2009

  • HY. Wang
  • et al

Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid.

PNAS . 2007 Apr 02 ; 104(15) 6412 | DOI : 10.1073/pnas.0701585104.

  • T. Kanekiyo
  • et al

Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients’ stratification in Alzheimer’s disease.

Transl Psychiatry . 2013 Jul 16 ; 8 e281 | DOI : 10.1038/tp.2013.58.

  • JD. Abraham
  • et al

Biotin–avidin interaction-based screening assay for Alzheimer’s β-peptide oligomer inhibitors.

Anal Biochem . 2006 May 11 ; 356(2) 265 | DOI : 10.1016/j.ab.2006.04.036.

  • H. Le Vine