Biotin-beta-Amyloid (1-42)
- Cat.Number : AS-23524-01
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Aß (1-42), a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Aß (1-42) is the principal species associated with senile plaque amyloids, while Aß (1-40) is more abundant in cerebrovascular amyloid deposit. This peptide is biotinylated at the N-terminus.
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Citations
Tailoring the antibody response to aggregated Aß using novel Alzheimer-Vaccines
PLoS One . 2015 Jan 22 ; 10(1) e0115237 | DOI : 10.1371/journal.pone.0115237
- M. Mandler
Apoptosis is directly related to intracellular amyloid accumulation in a cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down syndrome
Neurosci Lett . 2010 Feb 05 ; 470(1) 81 | DOI : https://doi.org/10.1016/j.neulet.2009.12.062
- C. Arriagada
Macrophage-Mediated Degradation of β-Amyloid via an Apolipoprotein E Isoform-Dependent Mechanism
J Neurosci . 2009 Mar 18 ; 29(11) 3603 | DOI : https://doi.org/10.1523/JNEUROSCI.5302-08.2009
- L. Zhao
Amyloid-β peptide binds to microtubule-associated protein 1B (MAP1B)
Neurochem Int . 2008 May 01 ; 52(6) 1030 | DOI : https://doi.org/10.1016/j.neuint.2007.10.020
- G. Gevorkian
Dissociating β-amyloid from α7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes α7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.
J Neurosci . 2009 Sep 02 ; 29(35) 10961 | DOI : 10.1523/JNEUROSCI.6088-08.2009
- HY. Wang
Lipocalin-type prostaglandin D synthase/β-trace is a major amyloid β-chaperone in human cerebrospinal fluid.
PNAS . 2007 Apr 02 ; 104(15) 6412 | DOI : 10.1073/pnas.0701585104.
- T. Kanekiyo
Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients’ stratification in Alzheimer’s disease.
Transl Psychiatry . 2013 Jul 16 ; 8 e281 | DOI : 10.1038/tp.2013.58.
- JD. Abraham
Biotin–avidin interaction-based screening assay for Alzheimer’s β-peptide oligomer inhibitors.
Anal Biochem . 2006 May 11 ; 356(2) 265 | DOI : 10.1016/j.ab.2006.04.036.
- H. Le Vine