IMG-EN-AS-62451-01.jpg
Peptides

Biotin-beta-Amyloid (25-35) - 1 mg

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  • Cat.Number : AS-62451
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This peptide is amino acids 25 to 35 fragment of the ß-amyloid biotinylated at C-terminus. This peptide possesses many of the characteristics of the full-length ß-amyloid peptide, including an amphiphilic nature and an ability to aggregate, and can serve as a model system to study the conformational changes involved in Alzheimer's disease. Aggregates of ß-amyloid (25–35) have been shown to possess the neurotrophic and neurotoxic properties of their full-length counterparts and there is evidence that the monomeric form of the peptide may itself be cytotoxic.

Specifications

Chemistry
Sequence one letter code
  • Biotin-GSNKGAIIGLM
Sequence three letter code
  • Biotin-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
Molecular Formula
  • C55H95N15O16S2
Molecular Mass/ Weight
  • 1286.7
Modification
Conjugation type
  • Biotins
Modification Name
Conjugation
  • Conjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • human

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References

Effects of Solvent on the Structure of the Alzheimer Amyloid-β(25–35) Peptide

Biophys . 2006 Sep 01 ; 91(5) 1638 | DOI : https://doi.org/10.1529/biophysj.105.079186

  • G. Wei
  • J. Shea