C-peptide, dog - 0.5 mg
- Cat.Number : AS-61128
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Insulin secretory rate can be estimated from peripheral C-peptide concentrations in dogs. Plasma C-peptide concentrations during glucagon stimulation testing is variable in diabetic dogs and may represent dogs with type-1 and type-2 diabetes or more likely, differences in severity of b-cell loss in dogs with type-1 diabetes.
Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.
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References
Basal and Glucagon-Stimulated Plasma C-PeDtide Concentrations in Healthy Dogs, Dogs With Diabetes Millitus, and Dogs With Hyperadrenocorticism
J Vet Intern Med . 1996 May 01 ; 10(3) 116 | DOI : https://doi.org/10.1111/j.1939-1676.1996.tb02042.x
- T. Montgomery
- et al
C-peptide and insulin secretion. Relationship between peripheral concentrations of C-peptide and insulin and their secretion rates in the dog.
J Clin Invest . 1984 Nov 01 ; 74(5) 1821 | DOI : 10.1172/JCI111601
- K. Polonsky
- et al