C-Peptide, human - 0.5 mg

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  • Cat.Number : AS-61127
  • Availability :
    In stock


C-peptide is cleaved from proinsulin, stored in secretory granules, and eventually released into the bloodstream in amounts equimolar with those of insulin. The measurement of the C-peptide is an important test for the β-cell function. In the red blood cells of type 2 diabetic patients, Na+,K+ ATPase activity is strongly related to blood C-peptide levels. C-peptide signal transduction in human renal tubular cells involves the activation of phospholipase C and PKC-d and PKC-varepsilon, as well as RhoA, followed by phosphorylation of ERK1/2 and JNK and a parallel activation of Akt. C-peptide shows specific binding to a G-protein-coupled membrane binding site, resulting in Ca2+ influx, activation of mitogen-activated protein kinase signalling pathways and stimulation of Na+, K+ ATPase and endothelial nitric oxide synthase.

Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.


Sequence one letter code
Sequence three letter code
  • H-Glu-Ala-Glu-Asp-Leu-Gln-Val-Gly-Gln-Val-Glu-Leu-Gly-Gly-Gly-Pro-Gly-Ala-Gly-Ser-Leu-Gln-Pro-Leu-Ala-Leu-Glu-Gly-Ser-Leu-Gln-OH
CAS registry number
  • 33017-11-7
Molecular Formula
  • C129H211N35O48
Molecular Mass/ Weight
  • 3020.5
  • Unconjugated
Quantity & Purity
  • Peak Area by HPLC ≥95%
Storage & stability
  • Lyophilized
Storage Conditions
  • - 20 °C
Biomarker Target
Research Area
Sub-category Research Area
  • Research use
Source / Species
  • human

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C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells

Diabetologia . 2004 Dec 29 ; 48(1) 187 | DOI : 10.1007/s00125-004-1602-5

  • Z. Zhong
  • et al

C-peptide, Na+,K+-ATPase, and Diabetes

Exp Diabesity Res . 2003 Jun 01 ; 5 37 | DOI :

  • P. Vague
  • et al

Estimation of Insulin Secretion Rates from C-Peptide Levels: Comparison of Individual and Standard Kinetic Parameters for C-Peptide Clearance

Diabetes . 1992 Mar 01 ; 41(3) 368 | DOI :

  • E. Van Cauter

Role of C-peptide in human physiology

Am. J. Physiol. Endocrinol. Metab . 2000 May 01 ; 278(5) E759 | DOI :

  • J. Wahren
  • et al