IMG-EN-AS-60844-01.jpg
Peptides

Calpain Inhibitor Peptide, B27-WT - 0.5 mg

$147.00
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  • Cat.Number : AS-60844
  • Availability :
    In stock

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Calpains are a family of intracellular Ca2+ dependent cysteine proteases. They respond to Ca2+ signals by cleaving many specific proteins, thereby irreversibly modifying their function(s). They are implicated in a variety of Ca2+ regulated cellular processes as well as various pathological phenomena, such as ischemic injury, muscular dystrophy, diabetes, cataract, atherosclerosis, Alzheimer’s disease, and cancer. Calpains represent potential therapeutic targets for drug discovery.
This 27-residue peptide is derived from subdomain 1B of the repetitive domains of calpain, named peptide B27-WT. It is a potent inhibitor of calpain.

Specifications

Chemistry
Sequence one letter code
  • DPMSSTYIEELGKREVTIPPKYRELLA
Sequence three letter code
  • H-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-OH
CAS registry number
  • 128578-18-7
Molecular Formula
  • C140H227N35O44S
Molecular Mass/ Weight
  • 3136.8
Modification
Conjugation
  • Unconjugated
Quantity & Purity
Purity
  • Peak Area by HPLC ≥95%
Storage & stability
Form
  • Lyophilized
Storage Conditions
  • - 20 °C
Activity
Application
Biomarker Target
Research Area
Sub-category Research Area
Usage
  • Research use
Source
Source / Species
  • Human, monkey

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References

Identification and Characterization of Inhibitory Sequences in Four Repeating Domains of the Endogenous Inhibitor for Calcium-Dependent Protease

Biochem . 1989 Aug 01 ; 106(2) 274 | DOI : https://doi.org/10.1093/oxfordjournals.jbchem.a122844

  • H. Kawasaki

Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene

J Biol Chem . 1989 Nov 01 ; 264(32) 18866 | DOI : https://doi.org/10.1016/S0021-9258(19)47235-9

  • M. Maki
  • et al

The β- and γ-CH2 of B27-WT's Leu11 and Ile18 Side Chains Play a Direct Role in Calpain Inhibition

Biochem. . 2004 Feb 07 ; 43(9) 2596 | DOI : https://doi.org/10.1021/bi0359832

  • R. Betts
  • J. Anagli

Structural Determinants of the Calpain Inhibitory Activity of Calpastatin Peptide B27-WT

J. Biol. Chem. . 2003 Mar 01 ; 278(10) 7800 | DOI : https://doi.org/10.1074/jbc.M208350200

  • R. Betts
  • et al

Stomatin is a major lipid-raft component of platelet α granules

Blood . 2002 Aug 01 ; 100(3) 897 | DOI : https://doi.org/10.1182/blood.V100.3.897

  • M. Mairhofer
  • et al